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Biochemical marker combinations are being developed as alternatives to liver biopsy in patients with chronic hepatitis C and other chronic liver diseases, including chronic hepatitis B, alcoholic liver disease, or non-alcoholic steatosis.

Aetna considers the following serum marker tests experimental and investigational for detecting or monitoring hepatic fibrosis in persons with hepatitis C or other chronic liver diseases (e.g., non-alcoholic fatty liver disease (NAFLD)) because their effectiveness for these indications has not been established: (not an all-inclusive list) Hepatic fibrosis is the excessive accumulation of fibrotic connective tissue resulting from prolonged inflammation and progressive scarring of the liver due to a sustained wound-healing response to alcohol or nonalcohol-induced liver injury (nonalcoholic liver disease includes, but not limited to, hepatitis B and hepatitis C infections).

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